What if enzymes could be the key to the COVID-19 vaccine?
Enzymes are biological catalysts that help break down substrates into products (digestion). They use a lock and key method which allows only specific substrates to fit in and be broken down by enzymes. What if we could genetically engineer a enzyme to have the entry point in the shape of the virus. This way, only the virus will be able to be broken down the enzyme. Viruses are shaped with “Envelopes” and “Envelope proteins” instead of cell membranes.
These are also made up of proteins, the Enzyme Protease is given the job to break down proteins, so if the Enzyme had similar DNA as protease (to break down the ”Envelope” and ”protein Envelope”) we could basically deconstruct the COVID-19 virus. As we all know enzymes remain chemically unchanged at the end of the reaction, meaning they can be reused. so this way, these enzymes dont die off easily.This means that the enzymes gives your body protection for a long amount of time.
However as enzymes have a optimum PH of 7(neutral) these enzymes will denature in areas with high PH levels such as the stomach(PH-2) or the dudenum (PH-8 OR 9).
So even though enzymes have a lot of potential it will still be a tough challenge to create a vaccine from enzymes.
This is just my hypotheses that i have thought of by piecing together what i have learnt about the COVID-19 and enzymes.
I am no science man…but this is a good read in terms of research. My question is how will it be implemented and how will enzymes be imparted on patients.
Greetings Mr.Mohanty,
I would like to answer this question by applying my knowledge to it from my research.
It would be possible to inject the enzymes in the body the same way vaccines inject the inactive part of a virus in your body. So we could basically just implant it on the patients by injecting them with a vaccine that would hold these enzymes. However, this would be less of a vaccine and more of a cure as it does not teach the body how to fend off the pathogen, instead it just fights along the body to kill the pathogen.
It would be implemented the same way around the world as any other medicine, it is just that the contents and how it would work will differ.
From the front runner in enzyme technology………
*From Kiran Mazumdar Shaw, Chairman, Biocon Limited — Covid19 Diary*
My first symptoms were a mild feverish feeling late evening on 16th August. I had felt similar symptoms in early June and I tested negative so I just took a Crocin n thought it would take care of it. The next morning though, I continued to feel feverish n I measured it – 99 F. That’s when I decided to test myself and my entire household as I have my 89 year old mother, a cancer survivor and my 71 year old husband, a cancer patient to worry about. I immediately self quarantined in a separate room and waited anxiously for the test results. At 5 pm I was told that I tested positive but that everyone else at home including my staff tested negative. Mercifully, the virus spared my mom and my husband. I asked for the CT (Cycle Threshold) value to assess my viral load and when I saw it was 23, I felt the load was safe enough to be home quarantined under tele-supervision. Dr Murli Mohan from Narayana Health, Bengaluru and Dr Shashank Joshi from Lilavati hospital, Mumbai, were my key medical supervisors. I was put on a course of Favipiravir, azithromycin and paracetamol. Apart from this, I continued with my daily dose of Vit C, Vit D, Zinc, baby aspirin and chyavanprash! Not to mention my twice a week 200mg dose of HCQ! Day 2 & 3 were uneventful. I was measuring my oxygen saturation levels 6 times a day which were all between 96-98% even after a brisk 6 minute walk. My temperature was normal but late evening on Day 3, I felt fluish n it extended to Day4 & 5. No measurable temperature but frequent bouts of sweating which suggested that my body was fighting the virus. I was also tracking my Cytokine levels. My cRP was normal at <0.5 throughout the infected period which indicated no inflammation. My D-Dimer and Ferritin levels were also within normal range. I also tracked my cytokine levels especially IL-6 which were undetectable. By Day 6, I started feeling better. My rtPCR test on Day 10 was still positive but with a CT value of 33 suggesting a very low and non infectious viral load generally attributed to dead virus shedding. I also tested my blood for antibodies n T-cells on Day 9. IgM was noticeably present but not IgG. My innate immune response based on Dendritic and NK cells was strong. A robust T cell activation was observed in my sample with a higher frequency of antigen specific T cells, effector T cells,Memory T cells and cytokine release on stimulation. I basically had developed T Cell immunity which could potentially protect me for a long duration. On Day 12 My rtPCR test was positive with a CT value of 36 heralding the final leg of my Covid19 saga!
My experience has been mild and uneventful. No loss of smell or taste n no drop in oxygen saturation. I recommend to everyone with mild fluish symptoms to test and decide on hospitalisation or home quarantine based on viral load: CT values <20 with fever ought not to home isolate. Monitoring oxygen saturation several times a day is psychologically good for your virus fighting morale. I also recommend that you try and exercise or go for a short walk every day to keep fit. I did not experience any loss of appetite and I suggest a diet of fruit, vegetables, lentils and cereal. Soups and salads were a daily feature for my meals. My constant companions were NETFLIX n Amazon Prime; avoid TV and social media as negative news are bad for fighting Covid19! My simple learnings:
1. Don’t panic on testing positive.
2. Make sure you assess your viral load based on CT value.
3. Mild symptoms with moderate viral load qualifies for home isolation.
4. Monitor your oxygen saturation several times a day to ensure it doesn’t drop below 95%
5. Make sure you are supervised by a doctor through a Telehealth program.
6. Do yoga and walk as much as you can.
7. Your body will fight the virus in a week.
8. Doctors should not just treat clinical Symptoms but rather the cause of the symptoms. Eg If SpO2 reduces, just increasing oxygen flow is not the answer. Treating inflammation caused by cytokines is the answer.
9. Lack of early intervention in mitigating the inflammation n cytokine storm can cause post Covid 19 fatigue and respiratory ailments.
10. Finally, please test and present yourself as soon as you feel mild symptoms. Do not be in denial n wait for more severe symptoms. You have reduced your chances of a mild disease by doing so.
Leveraging science to manage the virus is the only reliable way forward.
In June I was half hoping that I contracted COVID-19 to overcome the paranoia and the suspense that has taken over our lives. I was also expecting the infection to be mild n short lived. My Covid19 experience has matched these expectations and I hope that it allays the fear of the virus.